Eyebrow Mesotherapy with AQ Advanced Hair Complex+: What a 2024 Clinical Study Found

Most of what gets written about thin or thinning eyebrows in aesthetic medicine goes straight to correction rather than restoration — pencil, powder, microblading, tattooing, occasionally a transplant. What's had far less clinical attention, until recently, is treating the eyebrow the way dermatology already treats the scalp: as a hair-bearing area with follicles that can be biologically stimulated, not just cosmetically disguised.

A study published in the Journal of Cosmetic Dermatology in 2024 did exactly that, and it happens to have used AQ Advanced Hair Complex+ as its growth factor serum of choice. If your clinic already stocks AQ Hair Complex+ for scalp protocols, this is worth reading closely — it's essentially a published, peer-reviewed case for a second service line sitting inside inventory you may already have.

The Study, Briefly

The paper — Assessment of Clients' Perceptions and Satisfaction With Eyebrow Mesotherapy Treatment, by Dobroshi et al., published open-access in the Journal of Cosmetic Dermatology (2024, DOI: 10.1111/jocd.16699) — followed 32 healthy women aged 21 to 55 with thin, weakened, or fallen eyebrows, recruited through the Aesthetic and Dermatology Clinic "Estethica" in Prishtina. Each client underwent three eyebrow mesotherapy (EB MT) sessions spaced two to four weeks apart, using AQ Advanced Hair Complex+ as the injected serum.

Sessions ran around 40 minutes total — roughly 10 minutes of treatment per eyebrow, 5 minutes for disinfection, and 15 minutes allowed for absorption of the serum. Delivery used a professional mesotherapy device with disposable sterile microneedle tips (12 needles, 2.5mm cartridge), penetrating to a depth of 2.0–3.0mm. Two techniques were compared — "point by point" and "nappage" — with the researchers concluding point-by-point delivery had the greater impact, since it reaches deeper into the intradermal layer and opens channels that let the serum better penetrate down to the hair follicle itself, rather than sitting more superficially.

Why They Chose AQ Advanced Hair Complex+ Specifically

This is worth reading closely, because the researchers were explicit about their selection criteria rather than simply defaulting to a familiar brand. Before settling on AQ Advanced Hair Complex+, the team conducted research specifically looking for a growth-factor product without added growth hormones, evaluated against these criteria:

• The growth factors are referenced across multiple publications supporting their effectiveness in hair growth and regeneration

• Manufacturing takes place in a GMP and FDA-registered facility, meeting recognised production standards

• Production follows rigorous pharmaceutical standards for reliability and safety

• The product has an established safety record in clinical use

One small but telling detail from the paper: the researchers noted they even cross-checked their choice by asking an AI system which was the most efficient and effective growth factor product on the market, and got the same answer. It's a minor point, but it reflects the kind of due diligence a study team runs before committing a published protocol to a specific product — not incidental brand placement.

What the Results Showed

The headline numbers are strong enough to be worth stating plainly:

• GAIS (Global Aesthetic Improvement Scale) score: 8.28 out of 10 — physician-assessed, based on standardised before-and-after photography, where 10 represents the highest level of improvement

• NRSS (Numeric Rating Scale for Satisfaction): 8.06 out of 10 — client-reported satisfaction

• Pain: average 4.0 out of 10 — described as moderately low with high tolerability

• 90.6% of clients said they were willing to continue with further sessions

• 100% of clients said they would recommend the treatment to others

• More than 30% of clients gave the treatment the maximum satisfaction score of 10

On safety, the paper reported no adverse effects beyond mild, transient redness around the eyebrows that resolved within two to four hours, alongside a mild, well-tolerated level of discomfort during the procedure itself. Photographic and trichoscopic analysis after the first session already showed measurable increases in hair shaft thickness and eyebrow volume, with continued improvement in density and appearance tracked across the full three-session protocol.

The Part Worth Repeating to Patients: Why Shedding and Regrowth Both Happen Here

The biological logic tracks closely with what's already established for scalp hair — which makes sense, since eyebrow follicles go through the same anagen–catagen–telogen growth cycle as scalp follicles, just on a shorter anagen (growth) phase. The study's authors describe the mechanism as twofold: the multicomponent serum helps correct eyebrow loss by creating a more favourable biological environment for follicles still capable of producing hair, while the microneedling delivery itself increases local blood flow to the treated area, supplying the nutrients, micronutrients, and proteins that actively developing follicles need as they enter the anagen phase. Both resting (telogen-phase) follicles and already-active ones appear to respond — meaning the treatment isn't limited to eyebrows with only mild thinning.

The Part That's Easy to Underweight: Psychological Impact

The paper's introduction makes a point worth carrying into your own patient conversations: eyebrows carry outsized weight in how people read a face, communicate emotion, and judge attractiveness, and eyebrow loss — whether from over-plucking history, alopecia, ageing, or a medical cause — has a documented psychological toll. The study's authors describe an "unseen impact" alongside the measured aesthetic one: clients reporting increased self-confidence and more comfortable social interaction following treatment, independent of the purely visual improvement captured in photographs. For a treatment category that often gets filed under "cosmetic" in a slightly dismissive sense, that's a meaningful reframe — this is closer to the psychological weight hair-loss treatment already carries for the scalp.

What This Means for Your Clinic

If you're already stocking AQ Advanced Hair Complex+ for scalp protocols, eyebrow mesotherapy is close to a zero-additional-inventory service line — the same serum, a mesotherapy delivery device many clinics already own or could add cheaply, and a session structure (three treatments, two to four weeks apart) that mirrors protocols your team likely already runs for scalp hair loss.

It also sits in a category with relatively little dedicated clinical marketing in India right now. Most eyebrow-focused aesthetic content here is built around microblading, tattooing, or transplant — invasive or semi-permanent options with very different risk and downtime profiles. A published, evidence-backed, low-downtime regenerative alternative is a genuinely differentiated offering to bring to patients who've over-plucked, are dealing with early thinning, or simply don't want a semi-permanent pigment procedure.

Frequently Asked Questions

Is eyebrow mesotherapy the same treatment as scalp hair growth factor therapy? The underlying serum and biological mechanism are the same — AQ Advanced Hair Complex+ delivered via microneedling to stimulate follicle activity — but the technique, needle depth, and session timing are adapted for the eyebrow's smaller area and shorter hair growth cycle.

How many sessions does eyebrow mesotherapy typically require? The published protocol used three sessions spaced two to four weeks apart, with measurable improvement in thickness and volume visible after the very first session.

Is eyebrow mesotherapy painful? In the published study, average pain was rated 4.0 out of 10 — described as moderately low with high tolerability — with topical anaesthetic used at the patient's discretion depending on pain tolerance.

What are the side effects of eyebrow mesotherapy? The study reported no adverse events beyond mild, transient redness around the treated area that resolved within two to four hours post-procedure.

Can eyebrow mesotherapy help eyebrows affected by alopecia or over-plucking? The study's candidates included clients with minimal, moderate, and severe eyebrow hair loss, with the treatment appearing to stimulate both resting (telogen-phase) follicles and already-active ones — suggesting a range of thinning severities may respond.

Where can Indian clinics source AQ Advanced Hair Complex+? NW Aesthetics distributes AQ Advanced Hair Complex+ pan-India as part of the full AQ Skin Solutions range. Clinics interested in adding eyebrow mesotherapy as a service, or in GFIT® practitioner training, can reach out through nwaesthetics.in.

Reference: Dobroshi, K., Dodov, M. G., Crcarevska, M. S., Raichki, R. S., Qehaja, S. S., & Krasniqi, B. (2024). Assessment of Clients' Perceptions and Satisfaction With Eyebrow Mesotherapy Treatment. Journal of Cosmetic Dermatology. https://doi.org/10.1111/jocd.16699. Published open access under the Creative Commons Attribution License.

This article is intended for licensed dermatologists and aesthetic practices evaluating eyebrow mesotherapy as a service offering. Clinical outcomes reflect the findings of the cited published study; individual results and candidacy should be assessed by a qualified practitioner. For protocol guidance and product sourcing, contact the NW Aesthetics team.

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